Why oh why haven't I reviewed Gary Taube's epic science book, Good Calories Bad Calories yet? Mostly because I didn't think I could do it justice so I've kept putting it off! But now it's out in paperback and I simply must recommend it to all the science-minded among my readers. The first section meticulously documents how we came to believe that cutting fat in our diets was a good thing, how our diets came to be filled with refined carbohydrates, and the health consequences of this. He then goes on to talk about other diet and weight-related issues. Although I found the latter chapters to be a bit uneven, and I had some fairly minor disagreements here and there, this book should be on the bookshelf of anyone interested in diet, nutrition, and science. 
on Good Calories Bad Calories: Fats, Carbs, and the Controversial Science of Diet and Health
Be warned that this book is BIG and the sheer volume of science isn't everyone's cup of tea. If this is your case, then check out this article in the Missourian describing a recent talk Taubes gave.
Image Courtesy of Pricegrabber
Related Resources:
Splenda is NOT natural & is not healthy. Our bodies were not created to breakdown chemicals. Get the facts at:
http://www.truthaboutsplenda.com/
I had not seen this study with splenda, thanks for posting it. Has Duke Unisiversity Done any others?
So, I would say from the results, if you already have compromised immune system. . .”Splenda” is going to make it worse NOT better everytime you use it.